Revolutionary Breakthrough: Scientists Create Human Embryos from Skin Cells

Sat Oct 11 2025 09:59:46 GMT+0300 (Eastern European Summer Time)

US researchers have achieved a groundbreaking feat by generating human embryos from skin cell DNA, potentially changing reproductive possibilities for individuals and couples facing infertility.

For the first time, scientists in the US have successfully created early-stage human embryos using DNA extracted from skin cells, sparking discussions about the future of fertility treatments. This innovative technique could offer new solutions for infertility related to age and health issues, including allowing same-sex couples to have genetically related children. While the method shows promise, experts indicate further refinement is needed before it can be utilized in clinical settings, emphasizing the importance of public dialogue regarding the ethical implications of such advancements.

US scientists have, for the first time, made early-stage human embryos by manipulating DNA taken from people's skin cells and then fertilising it with sperm.

The technique could overcome infertility due to old age or disease, by using almost any cell in the body as the starting point for life.

It could even allow same-sex couples to have a genetically related child.

The method requires significant refinement - which could take a decade - before a fertility clinic could even consider using it.

Experts said it was an impressive breakthrough, but there needed to be an open discussion with the public about what science was making possible.

Reproduction used to be a simple story of man's sperm meets woman's egg. They fuse to make an embryo, and nine months later a baby is born.

Now scientists are changing the rules. This latest experiment starts with human skin.

The Oregon Health and Science University research team's technique takes the nucleus – which houses a copy of the entire genetic code needed to build the body – out of a skin cell.

This is then placed inside a donor egg that has been stripped of its genetic instructions.

So far, the technique is like the one used to create Dolly the Sheep – the world's first cloned mammal – born back in 1996.

However, this egg is not ready to be fertilised by sperm as it already contains a full suite of chromosomes.

You inherit 23 of these bundles of DNA from each of your parents for a total of 46, which the egg already has.

So the next stage is to persuade the egg to discard half of its chromosomes in a process the researchers have termed 'mitomeiosis' (the word is a fusion of mitosis and meiosis, the two ways cells divide).

The study, published in the journal Nature Communications, showed 82 functional eggs were made. These were fertilised with sperm and some progressed onto the early stages of embryos development. None were developed beyond the six-day-stage.

'We achieved something that was thought to be impossible,' said Prof Shoukhrat Mitalipov, the director of the Oregon Health and Science University's centre for embryonic cell and gene therapy.

The technique is far from polished as the egg randomly chooses which chromosomes to discard. It needs to end up with one of each of the 23 types to prevent disease, but ends up with two of some and none of others.

There is also a poor success rate (around 9%) and the chromosomes miss an important process where they rearrange their DNA, called crossing over.

Prof Mitalipov, a world-renowned pioneer in the field, stated the necessity for perfecting this groundbreaking method.

This technology is part of a growing field aiming to make sperm and eggs outside of the body, known as in vitro gametogenesis.

The approach is still at the level of scientific discovery rather than clinical use.

Additionally, the technique opens the door to same-sex couples having children that are genetically related to both partners, changing perspectives on parenthood.