At least 25 Palestinians were killed in Israeli strikes across the Gaza Strip on Wednesday, the Hamas-run health ministry has said, in what was one of the deadliest days since the ceasefire came into effect five weeks ago.

Ten people were killed when a ministry of religious endowments building in the eastern Zeitoun neighbourhood of Gaza City was hit, according to rescuers.

Israel's military stated it targeted Hamas terrorist targets after gunmen opened fire towards an area where its soldiers were operating in the southern city of Khan Younis, a move labeled by Hamas as a dangerous escalation.

The latest violence follows the UN Security Council's recent resolution endorsing President Donald Trump's Gaza peace plan, designed to end the ongoing conflict and establishment of a transitional governance body.

Hamas condemned the strikes, urging the U.S. to enforce the ceasefire and halt Israeli attacks while Israel maintained the strikes were necessary due to threats from armed groups.

With ongoing tensions, questions loom over the future of the fragile peace that had been tentatively established, as the region watches closely for signs of further escalation.