Seven people were killed when a UPS cargo plane crashed while taking off from an airport in Louisville, Kentucky on Tuesday evening, the state's governor said.

At least 11 other people were injured when the freight plane exploded as it departed Louisville Muhammad Ali International Airport at around 17:15 local time (22:15 GMT), sending thick plumes of black smoke into the sky.

Kentucky Governor Andy Beshear stated that the plane's three crew members were likely among those who died, commenting that, Anyone who has seen the images and the video knows how violent this crash is. Officials indicated that those injured suffered very significant injuries and the death toll could rise.

UPS flight 2976, bound for Honolulu, Hawaii, was carrying 38,000 gallons (144,000 litres) of fuel when it skidded off the runway in Louisville and hit nearby buildings, resulting in explosions that engulfed at least two nearby businesses, including a petroleum recycling company. An initial shelter-in-place order was issued for a five-mile radius due to fears of further explosions and air pollution before being reduced to just one mile.

In a statement, the Louisville Metro Police Department Chief mentioned the crash site would be an ongoing active scene for the next several days. The cause of the incident remains unknown, with the National Transportation Safety Bureau (NTSB) leading the investigation.

As firefighting efforts continue, Louisville's Mayor and local officials expressed their grief, with UPS stating they are terribly saddened and committed to supporting those affected. The investigation continues as the community grapples with the tragic loss.

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